The Bioorganic Chemisty of Enzymatic Catalysis

The perspectives of both bio- and organic chemistry are balanced in this important and integrated examination of the workings of enzyme catalysis. This text offers for the first time a clear-cut example of the link between organic reaction mechanisms and the study of biochemistry (particularly enzymology)-a link that is sometimes mentioned but infrequently illustrated in practical study. A broad-based chemical background that includes descriptions of: Proton Transfer Catalysis by Fields (Salts and Solvents) Catalysis by Hydronium and Hydroxide Ions Catalysis of Organic Reactions by General Acids and Bases and Catalysis by Nucleophiles and Electrophiles is offered first in preparation for the more enzyme-specific material that follows. Throughout The Bioorganic Chemistry of Enzymatic Catalysis each chapter emphasizes the unity of the material, discussing physical organic concepts first, then relating them to enzyme model systems and finally to a total enzyme system or systems. Students will find the coverage of intramolecular catalysis, multiple catalysis, and catalysis by complexation presented here constitutes conclusive evidence of the strong ties that bind organic chemical catalysis and enzymatic catalysis. Numerous tables, illustrations, and references are included to further demonstrate the bond and to promote better understanding. Researchers in enzymology, biochemistry, and bioorganic laboratories will find this an excellent review guide to how enzyme catalysis works. It also provides a foundation for anyone interested in the development of new fast catalysts.Myron L. Bender is the author of 'The Bioorganic Chemisty of Enzymatic Catalysis', published 1984 under ISBN 9780471059912 and ISBN 0471059919.